Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 2/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577246 | 0.99 | KIT (0.40) | ACKR3KITSTAT3CHRM1PDGFRA | |
| SCHEMBL24577851 | 0.92 | CHRM1 (0.38) | ACKR3KITSTAT3CHRM1PDGFRA | |
| SCHEMBL24578906 | 0.91 | CHRM1 (0.39) | ACKR3KITSTAT3CHRM1PDGFRA | |
| SCHEMBL24577250 | 0.91 | NTRK1 (0.37) | KITSTAT3CHRM1PDGFRAHRH3 | |
| SCHEMBL24577196 | 0.90 | CHRM1 (0.36) | KITSTAT3CHRM1PDGFRAHRH3 | |
| SCHEMBL24577938 | 0.90 | CHRM1 (0.34) | KITSTAT3CHRM1PDGFRAHRH3 | |
| SCHEMBL24578970 | 0.89 | CHRM1 (0.38) | KITSTAT3CHRM1PDGFRAHRH3 | |
| SCHEMBL24577940 | 0.88 | CHRM1 (0.35) | CHRM1PDGFRAHRH3MARK3JAK2 | |
| SCHEMBL24578949 | 0.88 | CHRM1 (0.35) | CHRM1PDGFRAHRH3MARK3JAK2 | |
| SCHEMBL24577243 | 0.88 | CHRM1 (0.35) | CHRM1PDGFRAHRH3MARK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |