Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 5/20 | 0.34 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.34 |
| ▸ | WNT1 | P04628 | 3/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577243 | 1.00 | CHRM1 (0.35) | CHRM1PDGFRAHRH3MARK3GSK3B | |
| SCHEMBL24577940 | 1.00 | CHRM1 (0.35) | CHRM1PDGFRAHRH3MARK3GSK3B | |
| SCHEMBL24577196 | 0.96 | CHRM1 (0.36) | CHRM1PDGFRAHRH3MARK3NTRK1 | |
| SCHEMBL24577250 | 0.95 | NTRK1 (0.37) | CHRM1PDGFRAHRH3MARK3GSK3B | |
| SCHEMBL24577938 | 0.90 | CHRM1 (0.34) | CHRM1PDGFRAHRH3MARK3GSK3B | |
| SCHEMBL24577246 | 0.89 | KIT (0.40) | CHRM1PDGFRAHRH3MARK3 | |
| SCHEMBL24577253 | 0.88 | ACKR3 (0.39) | CHRM1PDGFRAHRH3MARK3JAK2 | |
| SCHEMBL24578906 | 0.86 | CHRM1 (0.39) | CHRM1PDGFRAHRH3MARK3GSK3B | |
| SCHEMBL24578970 | 0.86 | CHRM1 (0.38) | CHRM1PDGFRAHRH3MARK3GSK3B | |
| SCHEMBL24577851 | 0.85 | CHRM1 (0.38) | CHRM1PDGFRAHRH3MARK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |