Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759572 | 1.00 | PDGFRA (0.60) | PDGFRACHRM1HRH3PDCD1CD274 | |
| SCHEMBL24577521 | 0.89 | PDGFRA (0.62) | PDGFRACHRM1HRH3KIT | |
| SCHEMBL29759431 | 0.89 | PDGFRA (0.62) | PDGFRACHRM1HRH3KIT | |
| SCHEMBL29759669 | 0.87 | PDGFRA (0.45) | PDGFRACHRM1HRH3ABL1TRPV1 | |
| SCHEMBL24577231 | 0.87 | PDGFRA (0.45) | PDGFRACHRM1HRH3ABL1TRPV1 | |
| SCHEMBL30809574 | 0.86 | PDGFRA (0.59) | PDGFRACHRM1HRH3 | |
| SCHEMBL24577235 | 0.86 | PDGFRA (0.64) | PDGFRACHRM1HRH3KIT | |
| SCHEMBL24578594 | 0.86 | PDGFRA (0.66) | PDGFRACHRM1HRH3PIK3CAKIT | |
| SCHEMBL29759529 | 0.86 | PDGFRA (0.66) | PDGFRACHRM1HRH3PIK3CAKIT | |
| SCHEMBL29759449 | 0.86 | PDGFRA (0.64) | PDGFRACHRM1HRH3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |