Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | CSK | P41240 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29760036 | 1.00 | KDR (0.34) | KDRWNT1GSK3BDYRK1ATRPV1 | |
| SCHEMBL24578251 | 0.88 | KDR (0.37) | KDRABL1PDGFRALCKCSK | |
| SCHEMBL24579122 | 0.88 | WNT1 (0.35) | WNT1GSK3BDYRK1APDGFRACHRM1 | |
| SCHEMBL29759698 | 0.88 | WNT1 (0.35) | WNT1GSK3BDYRK1APDGFRACHRM1 | |
| SCHEMBL30897455 | 0.87 | WNT1 (0.35) | WNT1GSK3BDYRK1AABL1PDGFRA | |
| SCHEMBL27185208 | 0.87 | WNT1 (0.35) | WNT1GSK3BDYRK1AABL1PDGFRA | |
| SCHEMBL30809573 | 0.85 | WNT1 (0.34) | WNT1GSK3BDYRK1APDGFRACHRM1 | |
| SCHEMBL24579107 | 0.85 | WNT1 (0.35) | WNT1GSK3BDYRK1APDGFRACHRM1 | |
| SCHEMBL29760014 | 0.85 | WNT1 (0.35) | WNT1GSK3BDYRK1APDGFRACHRM1 | |
| SCHEMBL29760123 | 0.85 | WNT1 (0.37) | WNT1GSK3BDYRK1APDGFRACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |