Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.31 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759653 | 0.88 | CSF1R (0.42) | CSF1RKITGSK3BDYRK1ADGAT1 | |
| SCHEMBL24576975 | 0.88 | CSF1R (0.42) | CSF1RKITGSK3BDYRK1ADGAT1 | |
| SCHEMBL30809568 | 0.86 | CSF1R (0.34) | CSF1RKITGSK3BDYRK1ADGAT1 | |
| SCHEMBL30809567 | 0.86 | CSF1R (0.34) | CSF1RKITGSK3BDYRK1ADGAT1 | |
| SCHEMBL29759628 | 0.85 | PDGFRA (0.34) | CSF1RKITIKBKETBK1PDGFRA | |
| SCHEMBL24579039 | 0.85 | PDGFRA (0.34) | CSF1RKITIKBKETBK1PDGFRA | |
| SCHEMBL24577084 | 0.85 | IKBKE (0.37) | CSF1RKITGSK3BDYRK1AIKBKE | |
| SCHEMBL24579009 | 0.84 | RAF1 (0.34) | CSF1RKITGSK3BDYRK1AIRAK4 | |
| SCHEMBL24578858 | 0.84 | IRAK4 (0.33) | CSF1RKITGSK3BDYRK1ADGAT1 | |
| SCHEMBL29759528 | 0.84 | IRAK4 (0.33) | CSF1RKITGSK3BDYRK1ADGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |