Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809568 | 1.00 | CSF1R (0.34) | CSF1RKITRORCEGLN2GSK3B | |
| SCHEMBL29759653 | 0.87 | CSF1R (0.42) | CSF1RKITRORCGSK3BDYRK1A | |
| SCHEMBL24576975 | 0.87 | CSF1R (0.42) | CSF1RKITRORCGSK3BDYRK1A | |
| SCHEMBL24577348 | 0.86 | CSF1R (0.34) | CSF1RKITRORCEGLN2GSK3B | |
| SCHEMBL30809541 | 0.85 | PDGFRA (0.35) | CSF1RKITIRAK4PIK3C3CHRM1 | |
| SCHEMBL24577084 | 0.84 | IKBKE (0.37) | CSF1RKITGSK3BDYRK1AIRAK4 | |
| SCHEMBL24577987 | 0.84 | LCK (0.37) | CSF1RKITRORCGSK3BDYRK1A | |
| SCHEMBL29759686 | 0.83 | KIT (0.33) | CSF1RKITRORCGSK3BDYRK1A | |
| SCHEMBL24579033 | 0.83 | KIT (0.33) | CSF1RKITRORCGSK3BDYRK1A | |
| SCHEMBL30809572 | 0.83 | IKBKE (0.35) | IRAK4PIK3C3CHRM1PDGFRAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |