Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 7/20 | 0.36 |
| ▸ | F10 | P00742 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | F9 | P00740 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2457720 | 0.88 | IGF1R (0.34) | SPHK1SPHK2BTKIGF1RF10 | |
| SCHEMBL2457199 | 0.86 | IGF1R (0.34) | SPHK1SPHK2BTKIGF1RF10 | |
| SCHEMBL2457743 | 0.85 | KDM4E (0.34) | SPHK1SPHK2BTKIGF1RF10 | |
| SCHEMBL2460164 | 0.85 | ACACB (0.35) | SPHK2IGF1RF10 | |
| SCHEMBL2462745 | 0.85 | IGF1R (0.34) | BTKIGF1RF10F9 | |
| SCHEMBL2461705 | 0.84 | KCNH2 (0.32) | SPHK1SPHK2BTKIGF1RF10 | |
| SCHEMBL5115303 | 0.83 | IGF1R (0.35) | SPHK1SPHK2BTKIGF1RF10 | |
| SCHEMBL2460493 | 0.83 | IGF1R (0.52) | SPHK1SPHK2BTKIGF1RF10 | |
| SCHEMBL5109184 | 0.82 | IGF1R (0.34) | SPHK1SPHK2BTKIGF1RF10 | |
| SCHEMBL2460551 | 0.82 | IGF1R (0.48) | SPHK1SPHK2BTKIGF1RF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675860-B1 | IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS | OSI PHARM INC (US) | 2011-09-21 | — | — | EP | claimed |
| EP-1675860-B1 | IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS | OSI PHARM INC (US) | 2011-09-21 | — | — | EP | disclosed |
| US-7459554-B2 | Imidazopyrazine tyrosine kinase inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2008-12-02 | — | — | US | disclosed |