Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.33 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5109184 | 0.96 | IGF1R (0.34) | IGF1RKCNH2BTKF10JAK2 | |
| SCHEMBL2457199 | 0.88 | IGF1R (0.34) | IGF1RKCNH2BTKF10JAK2 | |
| SCHEMBL2457720 | 0.85 | IGF1R (0.34) | IGF1RKCNH2BTKF10JAK2 | |
| SCHEMBL2460551 | 0.84 | IGF1R (0.48) | IGF1RKCNH2BTKF10JAK2 | |
| SCHEMBL2462745 | 0.84 | IGF1R (0.34) | IGF1RKCNH2BTKF10JAK2 | |
| SCHEMBL5106302 | 0.84 | PARP10 (0.36) | IGF1RKCNH2BTKF10SPHK1 | |
| SCHEMBL2463354 | 0.84 | IGF1R (0.39) | IGF1RKCNH2BTKF10JAK2 | |
| SCHEMBL2460657 | 0.84 | ADAM17 (0.39) | IGF1RKCNH2BTKF10JAK2 | |
| SCHEMBL2457374 | 0.84 | IGF1R (0.43) | IGF1RKCNH2F10JAK2JAK1 | |
| SCHEMBL2457738 | 0.83 | SPHK1 (0.37) | IGF1RBTKF10SPHK1SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459554-B2 | Imidazopyrazine tyrosine kinase inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2008-12-02 | — | — | US | disclosed |