Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759868 | 1.00 | CHRM1 (0.40) | CHRM1PDGFRAHRH3SIGMAR1IRAK4 | |
| SCHEMBL29759864 | 1.00 | CHRM1 (0.40) | CHRM1PDGFRAHRH3SIGMAR1IRAK4 | |
| SCHEMBL29759917 | 0.97 | CHRM1 (0.37) | CHRM1PDGFRAHRH3SIGMAR1CSF1R | |
| SCHEMBL24579068 | 0.97 | CHRM1 (0.37) | CHRM1PDGFRAHRH3SIGMAR1CSF1R | |
| SCHEMBL29759595 | 0.96 | CHRM1 (0.38) | CHRM1PDGFRAHRH3SIGMAR1 | |
| SCHEMBL29760161 | 0.92 | PDGFRA (0.46) | CHRM1PDGFRAHRH3IRAK4CSF1R | |
| SCHEMBL24578461 | 0.87 | ALDH1A1 (0.40) | — | |
| SCHEMBL24579109 | 0.87 | ALDH1A1 (0.39) | CHRM1PDGFRAHRH3 | |
| SCHEMBL29759935 | 0.87 | ALDH1A1 (0.39) | CHRM1PDGFRAHRH3 | |
| SCHEMBL29759499 | 0.86 | PDGFRA (0.46) | CHRM1PDGFRAHRH3IRAK4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |