Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 2/20 | 0.32 |
| ▸ | WNT1 | P04628 | 4/20 | 0.31 |
| ▸ | GSK3B | P49841 | 4/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.30 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.30 |
| ▸ | POLQ | O75417 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759586 | 1.00 | IRAK4 (0.33) | IRAK4CCNT1CDK9WNT3AWNT1 | |
| SCHEMBL24577464 | 0.93 | WNT3A (0.34) | IRAK4CCNT1CDK9WNT3AWNT1 | |
| SCHEMBL24578250 | 0.92 | WNT3A (0.34) | IRAK4CCNT1CDK9WNT3AWNT1 | |
| SCHEMBL24577950 | 0.91 | WNT3A (0.32) | IRAK4CCNT1CDK9WNT3AWNT1 | |
| SCHEMBL29759805 | 0.91 | WNT3A (0.32) | IRAK4CCNT1CDK9WNT3AWNT1 | |
| SCHEMBL30566527 | 0.90 | POLQ (0.37) | IRAK4CCNT1CDK9WNT1GSK3B | |
| SCHEMBL27185047 | 0.90 | POLQ (0.37) | IRAK4CCNT1CDK9WNT1GSK3B | |
| SCHEMBL29759708 | 0.89 | CCNT1 (0.35) | IRAK4CCNT1CDK9RAF1BRAF | |
| SCHEMBL24579079 | 0.89 | CCNT1 (0.35) | IRAK4CCNT1CDK9RAF1BRAF | |
| SCHEMBL24577425 | 0.89 | CHRM1 (0.40) | IRAK4CCNT1CDK9RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |