Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 5/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759889 | 0.89 | PDGFRA (0.38) | IRAK4IKBKETBK1JAK2JAK1 | |
| SCHEMBL24577201 | 0.88 | LMNA (0.39) | IRAK4LMNAIKBKETBK1CHRM1 | |
| SCHEMBL24577111 | 0.86 | PDGFRA (0.44) | IRAK4LMNAHTTIKBKETBK1 | |
| SCHEMBL24578010 | 0.82 | DYRK1A (0.37) | LMNAHTTCHRM1PDGFRAHRH3 | |
| SCHEMBL29760097 | 0.80 | MAPK13 (0.39) | IRAK4LMNAHTTCYP3A4CHRM1 | |
| SCHEMBL24577215 | 0.80 | KDR (0.41) | IRAK4LMNAHTTJAK2JAK1 | |
| SCHEMBL29759689 | 0.80 | PDGFRA (0.48) | IRAK4IKBKETBK1CHRM1PDGFRA | |
| SCHEMBL29759764 | 0.79 | PDGFRA (0.46) | IRAK4CHRM1PDGFRAHRH3 | |
| SCHEMBL24579099 | 0.77 | PDGFRA (0.36) | IRAK4EPHB3CHRM1PDGFRAHRH3 | |
| SCHEMBL24577731 | 0.77 | PIK3C3 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |