Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | PRKACG | P22612 | 1/20 | 0.31 |
| ▸ | PRKACB | P22694 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2457788 | 1.00 | TAS1R3 (0.37) | TAS1R3TAS1R1TAS1R2PFKFB3PREP | |
| SCHEMBL4092551 | 0.80 | CYP2C19 (0.40) | TAS1R3TAS1R1TAS1R2PFKFB3BRAF | |
| SCHEMBL4092549 | 0.80 | CYP2C19 (0.40) | TAS1R3TAS1R1TAS1R2PFKFB3BRAF | |
| SCHEMBL11234784 | 0.79 | HTT (0.47) | HTTROCK2ROCK1 | |
| SCHEMBL11234786 | 0.79 | HTT (0.47) | HTTROCK2ROCK1 | |
| SCHEMBL13890754 | 0.74 | KDM4E (0.47) | TAS1R3TAS1R1TAS1R2PFKFB3PREP | |
| SCHEMBL14318191 | 0.72 | RECQL (0.44) | HTT | |
| SCHEMBL5760734 | 0.71 | HTT (0.61) | PFKFB3HTT | |
| SCHEMBL5760737 | 0.71 | HTT (0.61) | PFKFB3HTT | |
| SCHEMBL3114077 | 0.70 | JMJD6 (0.56) | TAS1R3TAS1R1TAS1R2HTTJMJD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367687-B2 | Pyrazole derivatives | NOVARTIS AG (CH) | 2013-02-05 | — | — | US | disclosed |
| EP-2231636-B1 | PYRAZOLE DERIVATIVES AND USE THEREOF AS INHIBITORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2011-09-14 | — | — | EP | disclosed |
| US-20100280033-A1 | Pyrazole Derivatives | NOVARTIS AG | 2010-11-04 | — | — | US | disclosed |
| EP-2231636-A1 | PYRAZOLE DERIVATIVES AND USE THEREOF AS INHIBITORS OF CYCLIN DEPENDENT KINASES | Novartis AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009071701-A1 | PYRAZOLE DERIVATIVES AND USE THEREOF AS INHIBITORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280033-A1 | Pyrazole Derivatives | PRKDC, PRKACA, PDK2 | TAS1R3 3741/4885TAS1R1 3973/4885TAS1R2 4014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.