Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24576978 | 0.91 | GSK3B (0.41) | WNT1GSK3BDYRK1A | |
| SCHEMBL24578930 | 0.89 | WNT1 (0.31) | WNT1GSK3BDYRK1A | |
| SCHEMBL24578927 | 0.88 | WNT1 (0.35) | WNT1GSK3BDYRK1AJAK1JAK3 | |
| SCHEMBL24577401 | 0.88 | WNT1 (0.32) | WNT1GSK3BDYRK1A | |
| SCHEMBL24577267 | 0.87 | WNT1 (0.33) | WNT1GSK3BDYRK1A | |
| SCHEMBL24577970 | 0.85 | WNT1 (0.34) | WNT1GSK3BDYRK1A | |
| SCHEMBL24577767 | 0.84 | WNT1 (0.32) | WNT1GSK3BDYRK1A | |
| SCHEMBL24579091 | 0.83 | POLQ (0.32) | — | |
| SCHEMBL24577347 | 0.83 | WNT1 (0.33) | WNT1GSK3BDYRK1A | |
| SCHEMBL24577557 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |