Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 7/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 3/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | AXL | P30530 | 2/20 | 0.31 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | LYN | P07948 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24578809 | 0.90 | KIT (0.40) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL29759890 | 0.88 | IKBKE (0.38) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL29759768 | 0.86 | IKBKE (0.42) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL24577098 | 0.86 | IKBKE (0.42) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL24577084 | 0.85 | IKBKE (0.37) | IKBKETBK1PDGFRACHRM1HRH3 | |
| Hydrochloric Acid SCHEMBL30566540 | 0.85 | IKBKE (0.42) | IKBKETBK1PDGFRACHRM1HRH3 | |
| Hydrochloric Acid SCHEMBL27185082 | 0.85 | IKBKE (0.42) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL24577887 | 0.84 | WNT1 (0.37) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL24578953 | 0.83 | IKBKE (0.44) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL24577321 | 0.83 | WNT1 (0.38) | IKBKETBK1PDGFRACHRM1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |