Fenclonine

Fenclonine

SCHEMBL245828

N[C@H](Cc1ccc(Cl)cc1)C(=O)O

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 3/20 0.69
PTGS1 P23219 3/20 0.68
ALPI P09923 1/20 0.68
PKM P14618 1/20 0.68
XIAP P98170 1/20 0.68
HIF1A Q16665 5/20 0.58
CYP3A4 P08684 3/20 0.58
ALOX15 P16050 3/20 0.58
ALDH1A1 P00352 2/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
TDP1 Q9NUW8 2/20 0.58
KDM4E B2RXH2 2/20 0.58
SLC6A3 Q01959 2/20 0.58
ABCB11 O95342 1/20 0.58
CHRM2 P08172 1/20 0.58
ADRA2A P08913 1/20 0.58
CHRM1 P11229 1/20 0.58
ACHE P22303 1/20 0.58
OPRM1 P35372 1/20 0.58
DRD3 P35462 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fenclonine SCHEMBL26382 1.00 SLC7A5 (0.69) SLC7A5PTGS1ALPIPKMXIAP
Fenclonine SCHEMBL26383 1.00 SLC7A5 (0.69) SLC7A5PTGS1ALPIPKMXIAP
Fenclonine SCHEMBL3140768 1.00 SLC7A5 (0.69) SLC7A5PTGS1ALPIPKMXIAP
Fenclonine SCHEMBL6357978 0.98 SLC7A5 (0.67) SLC7A5PTGS1ALPIPKMXIAP
Fenclonine SCHEMBL16825893 0.98 SLC7A5 (0.67) SLC7A5PTGS1ALPIPKMXIAP
Fenclonine SCHEMBL988270 0.98 SLC7A5 (0.67) SLC7A5PTGS1ALPIPKMXIAP
Fenclonine SCHEMBL28422788 0.94 SLC7A5 (0.79) SLC7A5PTGS1ALPIPKMXIAP
SCHEMBL30722994 0.94 SLC7A5 (0.62) SLC7A5PTGS1ALPIPKMXIAP
SCHEMBL20714933 0.94 SLC7A5 (0.62) SLC7A5PTGS1ALPIPKMXIAP
Fenclonine SCHEMBL8497239 0.94 SLC7A5 (0.79) SLC7A5PTGS1ALPIPKMXIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 897 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260098072-A1 METHODS OF STIMULATING APPETITE AND/OR INCREASING BODY WEIGHT USING NON-NATURALLY OCCURRING MELANOCORTIN RECEPTOR ANTAGONIST ANALOGS ENDEVICA BIO INC (US) 2026-04-09 US claimed
US-20260077073-A1 GASTRIN-RELEASING PEPTIDE RECEPTOR (GRPR)-TARGETED COMPOUNDS AND USES THEREOF ALPHA 9 ONCOLOGY INC (CA) 2026-03-19 US claimed
EP-4696700-A1 LONG-ACTING K-OPIOID RECEPTOR AGONIST Chengdu Aoda Biotechnology Co., Ltd (CN) 2026-02-18 EP claimed
EP-4696699-A1 ? OPIOID RECEPTOR AGONIST AND USE THEREOF Chengdu Aoda Biotechnology Co., Ltd. (CN) 2026-02-18 EP claimed
EP-4665374-A1 METHODS OF PREVENTING AND/OR TREATING SIDE EFFECTS ASSOCIATED WITH ANTI-CANCER AGENTS USING NON-NATURALLY OCCURRING MELANOCORTIN ANALOGS WITH ANTI-GDF-15 ANTIBODIES Endevica Bio, Inc. (US) 2025-12-24 EP claimed
WO-2025245294-A1 NON-NATURALLY OCCURRING MELANOCORTIN RECEPTOR AGONISTS AND USES THEREOF FOR MODULATING WEIGHT GAIN ENDEVICA BIO, INC. (US) 2025-11-27 WO claimed
WO-2025245292-A1 NON-NATURALLY OCCURRING MELANOCORTIN RECEPTOR AGONISTS AND USES THEREOF FOR MODULATING WEIGHT LOSS ENDEVICA BIO, INC. (US) 2025-11-27 WO claimed
WO-2025245288-A1 NON-NATURALLY OCCURRING MELANOCORTIN ANALOGS AND USES THEREOF ENDEVICA BIO, INC. (US) 2025-11-27 WO claimed
WO-2025245279-A1 NON-NATURALLY OCCURRING MELANOCORTIN RECEPTOR AGONISTS AND USE THEREFORE IN TREATMENT OF ADDICTION AND/OR PAIN ENDEVICA BIO, INC. (US) 2025-11-27 WO claimed
EP-4605407-A2 METHODS OF STIMULATING APPETITE AND/OR INCREASING BODY WEIGHT USING NON-NATURALLY OCCURRING MELANOCORTIN RECEPTOR ANTAGONIST ANALOGS Endevica Bio, Inc. (US) 2025-08-27 EP claimed
WO-2004098629-A1 GnRH CONJUGATES COMPRISING A PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2004-11-18 WO claimed
WO-2003006048-A1 COMBINATION OF CHIPS (CHEMOTAXIS INHIBITING PROTEIN FROM STAPHYLOCOCCUS AUREUS)-BASED COMPOUNDS JARI PHARMACEUTICALS B.V. (NL) 2003-01-23 WO claimed
US-RE37710-E1 IMAGING TUMOR IMMUNOMEDICS, INC. 2002-05-21 US claimed
US-5753206-A Radiometal-binding analogues of luteinizing hormone releasing hormone IMMUNOMEDICS, INC. (US) 1998-05-19 US claimed
EP-0836618-A1 RADIOMETAL-BINDING ANALOGUES OF LEUTENIZING HORMONE RELEASING HORMONE Immunomedics, Inc. (US) 1998-04-22 EP claimed
WO-1996040756-A1 RADIOMETAL-BINDING ANALOGUES OF LEUTENIZING HORMONE RELEASING HORMONE IMMUNOMEDICS, INC. (US) 1996-12-19 WO claimed
EP-0593491-B1 LUTEINIZING HORMONE RELEASING HORMONE ANTAGONIST PEPTIDES DEGHENGHI ROMANO (CH) 1996-10-23 EP claimed
EP-0593491-A1 LUTEINIZING HORMONE RELEASING HORMONE ANTAGONIST PEPTIDES. DEGHENGHI ROMANO (CH) 1994-04-27 EP claimed
WO-1992019651-A1 LUTEINIZING HORMONE RELEASING HORMONE ANTAGONIST PEPTIDES DEGHENGHI ROMANO (CH) 1992-11-12 WO claimed
US-4693993-A ANTIINFLAMMATORY VAVREK, RAYMOND J. 1987-09-15 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260098072-A1 METHODS OF STIMULATING APPETITE AND/OR INCREASING BODY WEIGHT USING NON-NATURALLY OCCURRING MELANOCORTIN RECEPTOR ANTAGONIST ANALOGS MC1R, MC4R, MC5R SLC7A5 161/4885PTGS1 2336/4885ALPI 455/4885
US-20260077073-A1 GASTRIN-RELEASING PEPTIDE RECEPTOR (GRPR)-TARGETED COMPOUNDS AND USES THEREOF GRPR, GIPR, GLP1R SLC7A5 670/4885PTGS1 1358/4885ALPI 1415/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.