⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride SCHEMBL2458283 | 1.00 | — | — | |
| SCHEMBL9860908 | 0.82 | — | — | |
| Tert-Butylamine SCHEMBL204754 | 0.76 | — | — | |
| Tert-Butylamine SCHEMBL6330044 | 0.71 | — | — | |
| Tert-Butylamine SCHEMBL7125928 | 0.71 | — | — | |
| Fluoride SCHEMBL28976069 | 0.71 | — | — | |
| SCHEMBL111550 | 0.68 | — | — | |
| SCHEMBL94353 | 0.68 | — | — | |
| Tert-Butylamine SCHEMBL5736553 | 0.68 | — | — | |
| Tert-Butylamine SCHEMBL8051 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026233-B2 | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2011-09-27 | — | — | US | disclosed |
| US-20090149443-A1 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA, INC. | 2009-06-11 | — | — | US | disclosed |
| EP-2029581-A1 | P38 INHIBITORS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007126871-A1 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-11-08 | — | — | WO | disclosed |