Sugi Predict

Sugi Predict / Compounds / SCHEMBL2458299

SCHEMBL2458299

SCHEMBL2458299

CN1CCN(CC2CCC(C3=C4C=NC=C[N+]4(N)C(c4cccc(OCc5ccccc5)c4)=N3)CC2)CC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 13/20 0.44
▸ CYP2D6 P10635 1/20 0.42
▸ HRH1 P35367 1/20 0.42
▸ HRH3 Q9Y5N1 1/20 0.42
▸ PRMT5 O14744 3/20 0.39
▸ INSR P06213 5/20 0.38
▸ LYN P07948 5/20 0.38
▸ FGFR1 P11362 5/20 0.38
▸ FLT4 P35916 5/20 0.38
▸ FLT3 P36888 5/20 0.38
▸ ERBB4 Q15303 4/20 0.38
▸ ROCK2 O75116 4/20 0.38
▸ STK3 Q13188 4/20 0.38
▸ ROCK1 Q13464 4/20 0.38
▸ PRKD2 Q9BZL6 4/20 0.38
▸ LCK P06239 4/20 0.38
▸ KIT P10721 4/20 0.38
▸ FLT1 P17948 4/20 0.38
▸ KDR P35968 4/20 0.38
▸ RET P07949 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2460121 0.93 IGF1R (0.43) IGF1RCYP2D6HRH1HRH3PRMT5
SCHEMBL2457164 0.93 IGF1R (0.51) IGF1RCYP2D6HRH1HRH3INSR
SCHEMBL2457030 0.93 IGF1R (0.51) IGF1RCYP2D6HRH1HRH3INSR
SCHEMBL2460342 0.92 IGF1R (0.50) IGF1RCYP2D6HRH1HRH3INSR
SCHEMBL2462992 0.92 IGF1R (0.50) IGF1RCYP2D6HRH1HRH3INSR
SCHEMBL2462616 0.91 IGF1R (0.44) IGF1RCYP2D6HRH1HRH3INSR
SCHEMBL2460663 0.91 IGF1R (0.52) IGF1RCYP2D6HRH1HRH3PRMT5
SCHEMBL2460388 0.91 PRMT5 (0.41) IGF1RHRH3PRMT5INSRLYN
SCHEMBL2457189 0.90 IGF1R (0.43) IGF1RCYP2D6HRH1HRH3INSR
SCHEMBL2460662 0.90 IGF1R (0.42) IGF1RCYP2D6HRH1HRH3INSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP claimed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US claimed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US claimed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US claimed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 IGF1R 1/4885CYP2D6 1169/4885HRH1 706/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885CYP2D6 1169/4885HRH1 706/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885CYP2D6 1169/4885HRH1 706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.