Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24582862 | 0.82 | KDM4E (0.45) | HTTPOLBGAALRRK2NPSR1 | |
| SCHEMBL24582863 | 0.82 | KDM4E (0.45) | HTTPOLBGAALRRK2NPSR1 | |
| SCHEMBL24583177 | 0.82 | KDM4E (0.45) | HTTPOLBGAALRRK2NPSR1 | |
| SCHEMBL311909 | 0.73 | ALDH1A1 (0.39) | HTTMAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL24582871 | 0.73 | HTT (0.44) | HTTPOLBHIF1AGAALRRK2 | |
| SCHEMBL24582108 | 0.71 | HTT (0.45) | HTTPOLBHIF1AGAALRRK2 | |
| SCHEMBL24582090 | 0.70 | HTT (0.44) | HTTPOLBHIF1AGAALRRK2 | |
| SCHEMBL24582094 | 0.68 | KDM4E (0.42) | HTTGAALRRK2NPSR1KDM4E | |
| SCHEMBL10665575 | 0.66 | HIF1A (0.34) | HTTPOLBHIF1AGAANPSR1 | |
| SCHEMBL10662975 | 0.66 | HTT (0.42) | HTTPOLBHIF1AGAALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136174-A1 | TRICYCLIC PYRIMIDINES AS CYCLIN-DEPENDENT KINASE 7 (CDK7) INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-30 | — | — | WO | disclosed |