⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19116077 | 0.82 | ADORA2A (0.35) | — | |
| SCHEMBL20132926 | 0.81 | CHEK1 (0.41) | — | |
| SCHEMBL22349061 | 0.79 | — | — | |
| SCHEMBL21302086 | 0.72 | ADORA2A (0.37) | — | |
| SCHEMBL22328040 | 0.72 | — | — | |
| SCHEMBL20114452 | 0.72 | MAPK1 (0.30) | — | |
| SCHEMBL18408662 | 0.64 | MAPT (0.58) | — | |
| SCHEMBL20132922 | 0.64 | LMNA (0.31) | — | |
| SCHEMBL9945875 | 0.64 | LMNA (0.34) | — | |
| SCHEMBL24427711 | 0.63 | CHEK1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025918-A1 | KRAS G12D Inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-01-25 | — | — | US | disclosed |
| US-20240025918-A1 | KRAS G12D Inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-01-25 | — | — | US | disclosed |
| US-20230203060-A1 | FUSED TRICYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | GENFLEET THERAPEUTICS (SHANGHAI) INC. (CN) | 2023-06-29 | — | — | US | disclosed |
| US-11377441-B2 | Covalent inhibitors of KRAS | ARAXES PHARMA LLC (US) | 2022-07-05 | — | — | US | disclosed |