Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.37 |
| ▸ | NNMT | P40261 | 15/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19667605 | 0.92 | PRMT5 (0.38) | PRMT5WDR77NNMTSLC22A12HRH2 | |
| SCHEMBL28482515 | 0.90 | PRMT5 (0.36) | PRMT5WDR77NNMT | |
| SCHEMBL24659488 | 0.83 | PRMT5 (0.36) | PRMT5WDR77NNMT | |
| SCHEMBL24090908 | 0.83 | PRMT5 (0.38) | PRMT5WDR77NNMT | |
| SCHEMBL31123701 | 0.83 | PRMT5 (0.36) | PRMT5WDR77NNMT | |
| SCHEMBL24659092 | 0.83 | PRMT5 (0.35) | PRMT5WDR77NNMTSLC22A12 | |
| SCHEMBL22495013 | 0.82 | PRMT5 (0.37) | PRMT5WDR77NNMT | |
| SCHEMBL22707737 | 0.82 | PRMT5 (0.35) | PRMT5WDR77NNMT | |
| SCHEMBL21129923 | 0.82 | PRMT5 (0.35) | PRMT5WDR77NNMT | |
| SCHEMBL31123740 | 0.82 | PRMT5 (0.35) | PRMT5WDR77NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |