Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 18/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 17/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22509649 | 0.89 | PRMT5 (0.33) | PRMT5WDR77 | |
| SCHEMBL22521454 | 0.80 | PRMT5 (0.42) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL29522691 | 0.80 | PRMT5 (0.42) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL23430012 | 0.80 | PRMT5 (0.42) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL21061719 | 0.80 | PRMT5 (0.42) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL22509637 | 0.78 | PRMT5 (0.39) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL21130306 | 0.78 | PRMT5 (0.39) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL22509871 | 0.76 | PRMT5 (0.37) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL22494884 | 0.75 | PRMT5 (0.46) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL22494921 | 0.75 | PRMT5 (0.46) | PRMT5WDR77ADKRAPGEF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |