SCHEMBL24596166

SCHEMBL24596166

NCCn1cnc2c(=O)n(-c3ccccc3Cl)c3nc(C(F)(F)F)ccc3c21

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAT2A P31153 15/20 0.55
CNR1 P21554 5/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29789852 1.00 MAT2A (0.55) MAT2ACNR1
SCHEMBL24596173 0.90 MAT2A (0.53) MAT2ACNR1
SCHEMBL29790020 0.90 MAT2A (0.53) MAT2ACNR1
SCHEMBL29789853 0.89 MAT2A (0.55) MAT2ACNR1
SCHEMBL24596267 0.89 MAT2A (0.55) MAT2ACNR1
SCHEMBL24596168 0.88 MAT2A (0.57) MAT2ACNR1
SCHEMBL29789886 0.88 MAT2A (0.57) MAT2ACNR1
SCHEMBL24596207 0.88 MAT2A (0.55) MAT2ACNR1
SCHEMBL29789941 0.88 MAT2A (0.55) MAT2ACNR1
SCHEMBL29111654 0.86 MAT2A (0.48) MAT2ACNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240124454-A1 TRICYCLIC COMPOUND AND USE THEREOF NANJING ZAIMING PHARMACEUTICAL CO., LTD. (CN) 2024-04-18 US disclosed
EP-4273146-A1 TRICYCLIC COMPOUND AND USE THEREOF Nanjing Zaiming Pharmaceutical Co., Ltd. (CN) 2023-11-08 EP disclosed
EP-4273146-A1 TRICYCLIC COMPOUND AND USE THEREOF Nanjing Zaiming Pharmaceutical Co., Ltd. (CN) 2023-11-08 EP disclosed
WO-2022143864-A1 TRICYCLIC COMPOUND AND USE THEREOF 江苏先声药业有限公司 2022-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124454-A1 TRICYCLIC COMPOUND AND USE THEREOF MAT2A, MNAT1, KAT2A MAT2A 1/4885CNR1 1847/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.