Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.65 |
| ▸ | RAB9A | P51151 | 7/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.60 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.60 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | PLAU | P00749 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462116 | 0.86 | MAPT (0.58) | NPC1RAB9ARXFP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2460273 | 0.85 | NPC1 (0.52) | NPC1RAB9ARXFP1ALDH1A1TP53 | |
| SCHEMBL2456526 | 0.85 | NPC1 (0.52) | NPC1RAB9ARXFP1ALDH1A1TP53 | |
| SCHEMBL2456420 | 0.85 | NPC1 (0.58) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL2456673 | 0.84 | MEN1 (0.62) | NPC1RAB9ARXFP1ALDH1A1TP53 | |
| SCHEMBL2459861 | 0.82 | JAK2 (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| Aniline SCHEMBL2489874 | 0.81 | NPC1 (0.47) | NPC1RAB9ARXFP1ALDH1A1TP53 | |
| SCHEMBL10055020 | 0.81 | NPC1 (0.94) | NPC1RAB9ARXFP1ALDH1A1TP53 | |
| SCHEMBL4254961 | 0.81 | RXFP1 (0.74) | NPC1RAB9ARXFP1ALDH1A1TP53 | |
| Benzamide SCHEMBL2489873 | 0.81 | NPC1 (0.49) | NPC1RAB9ARXFP1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044041-B2 | e.g. 4-Chloro-1-hydroxy-phthalazine-6-carboxylic acid [4-chloro-3'-(2-dimethylamino-ethoxy)-biphenyl-3-yl]-amide; multifunctioning protein kinase inhibitors; anticarcinogenic, antiinflammatory, antidiabetic agent, neurodegenerative diseases | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2011-10-25 | — | — | US | disclosed |
| US-20110237571-A1 | PHTHALAZINE DERIVATIVES | ARALDI GIAN-LUCA | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237571-A1 | PHTHALAZINE DERIVATIVES | CDK5, HIPK2, PACSIN2 | NPC1 2569/4885RAB9A 3930/4885RXFP1 4802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.