Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 7/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460273 | 0.95 | NPC1 (0.52) | NPC1RAB9ANLRP3MEN1KMT2A | |
| Aniline SCHEMBL2489874 | 0.92 | NPC1 (0.47) | NPC1RAB9ANLRP3MEN1KMT2A | |
| SCHEMBL2456526 | 0.91 | NPC1 (0.52) | NPC1RAB9ANLRP3MEN1KMT2A | |
| SCHEMBL2465647 | 0.84 | PPARG (0.49) | AURKAAURKBRPS6KB1 | |
| SCHEMBL2459883 | 0.81 | NPC1 (0.65) | NPC1RAB9ANLRP3KMT2AALDH1A1 | |
| SCHEMBL2459765 | 0.80 | PPARG (0.49) | MEN1KMT2AALDH1A1AURKARPS6KB1 | |
| SCHEMBL2457621 | 0.79 | RXFP1 (0.55) | MEN1KMT2AALDH1A1AURKARPS6KB1 | |
| SCHEMBL2459069 | 0.76 | RXFP1 (0.55) | MEN1KMT2AALDH1A1AURKARPS6KB1 | |
| SCHEMBL4986819 | 0.74 | CSNK2A1 (0.51) | MEN1KMT2AALDH1A1HTT | |
| SCHEMBL2465245 | 0.74 | ALDH1A1 (0.43) | NPC1MEN1KMT2AALDH1A1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044041-B2 | e.g. 4-Chloro-1-hydroxy-phthalazine-6-carboxylic acid [4-chloro-3'-(2-dimethylamino-ethoxy)-biphenyl-3-yl]-amide; multifunctioning protein kinase inhibitors; anticarcinogenic, antiinflammatory, antidiabetic agent, neurodegenerative diseases | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2011-10-25 | — | — | US | disclosed |
| US-20110237571-A1 | PHTHALAZINE DERIVATIVES | ARALDI GIAN-LUCA | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237571-A1 | PHTHALAZINE DERIVATIVES | CDK5, HIPK2, PACSIN2 | NPC1 2569/4885RAB9A 3930/4885NLRP3 3082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.