Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | SIK1 | P57059 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | WNK3 | Q9BYP7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29691644 | 0.99 | AURKA (0.58) | AURKAAURKBPDE3BPDE3ADNMT1 | |
| Hydrochloric Acid SCHEMBL26679818 | 0.99 | AURKA (0.58) | AURKAAURKBPDE3BPDE3ADNMT1 | |
| SCHEMBL24600630 | 0.85 | AURKA (0.43) | AURKAAURKBERBB2PTK6MAPK13 | |
| SCHEMBL26877838 | 0.83 | PTK6 (0.53) | AURKAAURKBERBB2PTK6MAPT | |
| Hydrochloric Acid SCHEMBL26679864 | 0.83 | AURKA (0.42) | AURKAAURKBERBB2PTK6MAPK13 | |
| Hydrochloric Acid SCHEMBL29691552 | 0.83 | AURKA (0.42) | AURKAAURKBERBB2PTK6MAPK13 | |
| Hydrochloric Acid SCHEMBL26679897 | 0.82 | AURKA (0.41) | AURKAAURKBPDE3BPDE3AERBB2 | |
| Hydrochloric Acid SCHEMBL29691566 | 0.82 | AURKA (0.41) | AURKAAURKBPDE3BPDE3AERBB2 | |
| Hydrochloric Acid SCHEMBL29691563 | 0.82 | PTK6 (0.52) | AURKAAURKBERBB2PTK6MAPT | |
| Hydrochloric Acid SCHEMBL26679853 | 0.82 | PTK6 (0.52) | AURKAAURKBERBB2PTK6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669726-A | Novel naphthyridinone derivatives having inhibitory activity against exonuclease-phosphodiesterase and use thereof | 谛希诺生物科技有限公司 | 2023-08-29 | — | — | CN | claimed |
| CN-116669726-A | Novel naphthyridinone derivatives having inhibitory activity against exonuclease-phosphodiesterase and use thereof | 谛希诺生物科技有限公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022146022-A1 | NOVEL NAPHTHYRIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE AND USE THEREOF | 주식회사 티씨노바이오사이언스 | 2022-07-07 | — | — | WO | disclosed |