Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22856494 | 1.00 | KDM4E (0.36) | KDM4EPOLBTDP1CYP1A2CYP2D6 | |
| SCHEMBL16676987 | 0.80 | PRMT3 (0.33) | — | |
| SCHEMBL25601454 | 0.80 | CA12 (0.40) | KDM4EPOLBTDP1CYP1A2CYP2D6 | |
| SCHEMBL20015152 | 0.79 | USP2 (0.32) | — | |
| SCHEMBL16659367 | 0.79 | USP2 (0.37) | — | |
| SCHEMBL18016998 | 0.78 | PRMT3 (0.34) | — | |
| SCHEMBL20448699 | 0.77 | CA12 (0.37) | KDM4EPOLBTDP1CYP1A2CYP2D6 | |
| SCHEMBL22930120 | 0.77 | KDM4E (0.44) | KDM4EPOLBTDP1CYP1A2CYP2D6 | |
| SCHEMBL10914222 | 0.77 | KDM4E (0.44) | KDM4EPOLBTDP1CYP1A2CYP2D6 | |
| SCHEMBL22837632 | 0.77 | KDM4E (0.44) | KDM4EPOLBTDP1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |