Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 4/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 5/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31548012 | 0.84 | PDE10A (0.38) | HSD11B1PDE10ASPRKDM4DPIK3CD | |
| SCHEMBL25122963 | 0.84 | PDE10A (0.38) | HSD11B1PDE10ASPRKDM4DPIK3CD | |
| SCHEMBL29751429 | 0.78 | SPR (0.38) | DDR1HSD11B1PDE10ASPRKDM4D | |
| SCHEMBL24607801 | 0.78 | SPR (0.38) | DDR1HSD11B1PDE10ASPRKDM4D | |
| SCHEMBL24607488 | 0.77 | AAK1 (0.39) | HSD11B1PDE10ASPRKDM4DPIK3CD | |
| SCHEMBL29751443 | 0.77 | AAK1 (0.39) | HSD11B1PDE10ASPRKDM4DPIK3CD | |
| SCHEMBL28504211 | 0.73 | AKR1C3 (0.46) | DDR1HSD11B1PDE10AKDM4DPIK3CD | |
| SCHEMBL24607452 | 0.72 | PIK3CD (0.33) | DDR1PDE10ASPRKDM4DPIK3CD | |
| SCHEMBL5536857 | 0.72 | NPY5R (0.52) | PDE10ANPY5RMEN1KMT2A | |
| SCHEMBL29197655 | 0.71 | MCHR1 (0.40) | DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4271664-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-11-08 | — | — | EP | disclosed |
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |