Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29751339 | 1.00 | NPC1 (0.33) | NPC1PDK4KLKB1 | |
| SCHEMBL31314092 | 0.84 | PDK4 (0.50) | PDK4 | |
| SCHEMBL30318014 | 0.78 | NPC1 (0.33) | NPC1 | |
| SCHEMBL24607711 | 0.78 | KLKB1 (0.34) | NPC1KLKB1 | |
| SCHEMBL24607714 | 0.78 | KLKB1 (0.34) | NPC1KLKB1 | |
| SCHEMBL29751235 | 0.78 | KLKB1 (0.34) | NPC1KLKB1 | |
| SCHEMBL24607716 | 0.78 | KLKB1 (0.34) | NPC1KLKB1 | |
| SCHEMBL29751581 | 0.78 | KLKB1 (0.34) | NPC1KLKB1 | |
| SCHEMBL29751040 | 0.78 | KLKB1 (0.34) | NPC1KLKB1 | |
| SCHEMBL24607712 | 0.77 | NPC1 (0.33) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |