Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 8/20 | 0.40 |
| ▸ | GRM5 | P41594 | 7/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | EED | O75530 | 2/20 | 0.39 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.39 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29751339 | 0.84 | NPC1 (0.33) | PDK4 | |
| SCHEMBL24607708 | 0.84 | NPC1 (0.33) | PDK4 | |
| SCHEMBL31314085 | 0.84 | PARP1 (0.35) | PDK4SCN9A | |
| SCHEMBL30289455 | 0.83 | BRD4 (0.43) | PDK4GRM1GRM5NAMPTGABRP | |
| SCHEMBL31281722 | 0.83 | PDK4 (0.41) | PDK4HTR6GRM1GRM5EED | |
| SCHEMBL31282008 | 0.83 | PDK4 (0.41) | PDK4HTR6GRM1GRM5EED | |
| SCHEMBL23536299 | 0.81 | TP53 (0.39) | — | |
| SCHEMBL29907270 | 0.80 | PDK4 (0.49) | PDK4HTR6GRM1GRM5NAMPT | |
| SCHEMBL27144161 | 0.80 | PDK4 (0.49) | PDK4HTR6GRM1GRM5NAMPT | |
| SCHEMBL25338150 | 0.78 | BACE1 (0.32) | PDK4GRM1GRM5SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4620470-A2 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2025-09-24 | — | — | EP | disclosed |
| EP-4615455-A2 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2025-09-17 | — | — | EP | disclosed |
| US-20250059164-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2025-02-20 | — | — | US | disclosed |
| WO-2024264017-A2 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2024-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059164-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | PDK4 1336/4885HTR6 3032/4885GRM1 2881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.