Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29751413 | 1.00 | PGR (0.42) | PGRCNR1PDK4NAMPTCDK9 | |
| SCHEMBL30288955 | 0.90 | NAMPT (0.49) | CNR1PDK4NAMPTCDK9GABRP | |
| SCHEMBL22619239 | 0.84 | PDK4 (0.43) | CNR1PDK4NAMPTCDK9TBK1 | |
| SCHEMBL30273513 | 0.82 | PGR (0.39) | PGRCNR1CDK9LMNAGABRP | |
| SCHEMBL2636488 | 0.77 | PDK4 (0.41) | PDK4NAMPTGABRPGABRDGABRA1 | |
| SCHEMBL27025908 | 0.76 | NAMPT (0.47) | PDK4NAMPTGRM1CDK7CDK13 | |
| SCHEMBL22928167 | 0.76 | NAMPT (0.41) | CNR1PDK4NAMPTCDK9TBK1 | |
| SCHEMBL22619202 | 0.75 | PIK3CD (0.43) | PDK4NAMPTTBK1CDK7CDK13 | |
| SCHEMBL22619097 | 0.75 | RIPK2 (0.42) | PDK4NAMPTCDK9TBK1GABRP | |
| SCHEMBL31749310 | 0.75 | NAMPT (0.40) | PDK4NAMPTCDK9TBK1GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |