SCHEMBL24608352

SCHEMBL24608352

CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(C(=O)C(C)(C)c3ccc(Cl)cc3)nc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29700922 1.00 RORC (0.61) RORC
SCHEMBL24608339 0.91 RORC (0.73) RORC
SCHEMBL24608344 0.90 RORC (0.60) RORC
SCHEMBL24608634 0.90 RORC (0.54) RORC
SCHEMBL24608343 0.90 RORC (0.65) RORC
SCHEMBL29700944 0.89 RORC (0.58) RORC
SCHEMBL24608517 0.89 RORC (0.58) RORC
SCHEMBL24608354 0.89 RORC (0.57) RORC
SCHEMBL24608323 0.89 RORC (0.60) RORC
SCHEMBL24608376 0.89 RORC (0.56) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4273129-A1 RORgammaT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shanghai Pharmaceuticals Holding Co., Ltd. (CN) 2023-11-08 EP disclosed
WO-2022143771-A1 RORγT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 上海医药集团股份有限公司 2022-07-07 WO disclosed
CN-114685363-A ROR gamma t regulator, preparation method and application thereof 上海医药集团股份有限公司 2022-07-01 CN disclosed