Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.37 |
| ▸ | SLC2A3 | P11169 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21217864 | 0.91 | ROCK2 (0.42) | ROCK2ROCK1NPC1CDK4CCND1 | |
| SCHEMBL22966757 | 0.86 | ROCK2 (0.54) | ROCK2ROCK1NPC1CDK4CCND1 | |
| SCHEMBL22966755 | 0.83 | ROCK2 (0.59) | ROCK2ROCK1SLC2A1SLC2A3MEN1 | |
| SCHEMBL21217525 | 0.81 | ROCK2 (0.58) | ROCK2ROCK1SLC2A1SLC2A3MEN1 | |
| SCHEMBL21217766 | 0.81 | CDK4 (0.33) | ROCK2ROCK1CDK4CCND1LMNA | |
| SCHEMBL21217523 | 0.80 | ROCK2 (0.58) | ROCK2ROCK1NPC1SLC2A1SLC2A3 | |
| SCHEMBL24094330 | 0.79 | ROCK2 (0.41) | ROCK2ROCK1SLC2A1SLC2A3 | |
| SCHEMBL22967054 | 0.79 | ROCK2 (0.53) | ROCK2ROCK1NPC1CDK4CCND1 | |
| SCHEMBL22966753 | 0.78 | ROCK2 (0.50) | ROCK2ROCK1NPC1SLC2A1SLC2A3 | |
| SCHEMBL22966735 | 0.77 | ROCK2 (0.49) | ROCK2ROCK1NPC1SLC2A1SLC2A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4026834-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | Redx Pharma Plc (GB) | 2022-07-13 | — | — | EP | disclosed |