Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | BLK | P51451 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | STK3 | Q13188 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21217821 | 0.89 | ROCK1 (0.60) | ROCK1MEN1KMT2AROCK2CLK2 | |
| SCHEMBL21217908 | 0.83 | MEN1 (0.52) | ROCK1MEN1KMT2AROCK2CLK4 | |
| SCHEMBL21217530 | 0.83 | ROCK2 (0.57) | ROCK1MEN1KMT2AROCK2CLK2 | |
| SCHEMBL24610279 | 0.83 | MEN1 (0.50) | ROCK1MEN1KMT2AROCK2CLK2 | |
| SCHEMBL24094211 | 0.82 | MEN1 (0.52) | ROCK1MEN1KMT2AROCK2CLK2 | |
| SCHEMBL22966736 | 0.82 | ROCK1 (0.51) | ROCK1MEN1KMT2AROCK2CLK2 | |
| SCHEMBL22966855 | 0.82 | MEN1 (0.51) | ROCK1MEN1KMT2AROCK2CLK2 | |
| SCHEMBL24094169 | 0.81 | NPC1 (0.55) | ROCK1MEN1KMT2AROCK2CLK4 | |
| SCHEMBL21217909 | 0.80 | ROCK2 (0.56) | ROCK1MEN1KMT2AROCK2CLK4 | |
| SCHEMBL22967018 | 0.80 | ROCK1 (0.71) | ROCK1ROCK2CLK2BLKCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4026834-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | Redx Pharma Plc (GB) | 2022-07-13 | — | — | EP | disclosed |