Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22966914 | 0.85 | ROCK1 (0.52) | ROCK2ROCK1CLK2BLKSTK3 | |
| SCHEMBL24610311 | 0.85 | AGPAT2 (0.42) | ROCK2ROCK1KDRDAPK3PRKD3 | |
| SCHEMBL24610250 | 0.81 | ROCK2 (0.42) | ROCK2ROCK1KDRCLK2BLK | |
| SCHEMBL24968634 | 0.79 | RET (0.36) | ROCK2ROCK1KDRCHEK1DAPK3 | |
| SCHEMBL21217768 | 0.76 | ROCK1 (0.37) | ROCK2ROCK1DHODH | |
| SCHEMBL21217913 | 0.76 | ROCK2 (0.54) | ROCK2ROCK1CLK2BLKSTK3 | |
| SCHEMBL21217619 | 0.75 | ROCK1 (0.52) | ROCK2ROCK1CLK2BLKSTK3 | |
| SCHEMBL21217622 | 0.75 | ROCK2 (0.53) | ROCK2ROCK1CLK2BLKSTK3 | |
| SCHEMBL22966856 | 0.75 | ROCK1 (0.52) | ROCK2ROCK1CLK2BLKSTK3 | |
| SCHEMBL24094235 | 0.75 | NPC1 (0.44) | ROCK2KDRDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4026834-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | Redx Pharma Plc (GB) | 2022-07-13 | — | — | EP | disclosed |