Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24610984 | 0.86 | OPRK1 (0.41) | TP53MAPTOPRK1ACHEOPRM1 | |
| SCHEMBL20670554 | 0.86 | OPRK1 (0.35) | TP53MAPTOPRK1ACHEOPRM1 | |
| SCHEMBL24610988 | 0.84 | OPRK1 (0.41) | TP53MAPTOPRK1ACHEOPRM1 | |
| SCHEMBL24611001 | 0.77 | OPRK1 (0.42) | TP53MAPTOPRK1ACHEOPRM1 | |
| SCHEMBL20670795 | 0.76 | OPRK1 (0.40) | TP53MAPTOPRK1OPRM1 | |
| SCHEMBL24610983 | 0.74 | OPRK1 (0.38) | TP53MAPTOPRK1ACHENPC1 | |
| SCHEMBL20670943 | 0.73 | OPRK1 (0.50) | TP53MAPTOPRK1OPRM1 | |
| SCHEMBL20670686 | 0.70 | OPRK1 (0.52) | TP53MAPTOPRK1ACHEOPRM1 | |
| SCHEMBL16945103 | 0.69 | OPRK1 (0.45) | TP53MAPTOPRK1ACHEMAPK1 | |
| SCHEMBL20670863 | 0.69 | OPRK1 (0.50) | OPRK1OPRM1HPGDNPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596069-B1 | KAPPA OPIOID RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO | SCRIPPS RESEARCH INST (US) | 2022-07-13 | — | — | EP | disclosed |