Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.67 |
| ▸ | RAB9A | P51151 | 13/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.61 |
| ▸ | RELA | Q04206 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.60 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278505 | 0.88 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL3112891 | 0.82 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL30073965 | 0.82 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL3266299 | 0.80 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL1819335 | 0.80 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL1856861 | 0.80 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL4846271 | 0.79 | PIK3CG (0.62) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL1304004 | 0.77 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL1818561 | 0.76 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL20542573 | 0.76 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364306-A1 | Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors | Amgen Inc. (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010057126-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2010-05-20 | — | — | WO | disclosed |