Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 1.00 |
| ▸ | ABL1 | P00519 | 5/20 | 1.00 |
| ▸ | ABL2 | P42684 | 5/20 | 1.00 |
| ▸ | PRKCA | P17252 | 1/20 | 1.00 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461249 | 0.88 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2459209 | 0.85 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2458392 | 0.85 | EGFR (0.78) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2460994 | 0.85 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2461158 | 0.83 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2463632 | 0.83 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL29406611 | 0.83 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2461133 | 0.83 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2460989 | 0.83 | EGFR (1.00) | EGFRABL1ABL2PRKCAKDR | |
| SCHEMBL2458367 | 0.83 | EGFR (0.76) | EGFRABL1ABL2PRKCAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041137-B1 | PYRROLOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2011-09-28 | — | — | EP | claimed |
| EP-2041137-B1 | PYRROLOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2011-09-28 | — | — | EP | disclosed |
| US-6096749-A | ANTITUMOR, EPIDERMAL GROWTH FACTOR | NOVARTIS CORPORATION (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0682027-B1 | Pyrrolopyrimidine derivatives with antiproliferative action | CIBA GEIGY AG (CH) | 1997-10-15 | — | — | EP | disclosed |
| EP-0682027-A1 | Pyrrolopyrimidine derivatives with antiproliferative action | CIBA-GEIGY AG (CH) | 1995-11-15 | — | — | EP | disclosed |