Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 15/20 | 0.48 |
| ▸ | JAK2 | O60674 | 14/20 | 0.48 |
| ▸ | TYK2 | P29597 | 14/20 | 0.48 |
| ▸ | JAK3 | P52333 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.34 |
| ▸ | CDK9 | P50750 | 4/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24615492 | 0.85 | JAK1 (0.50) | JAK1JAK2TYK2JAK3KDR | |
| SCHEMBL24615496 | 0.85 | JAK2 (0.56) | JAK1JAK2TYK2JAK3KDR | |
| SCHEMBL29772796 | 0.84 | JAK1 (0.46) | JAK1JAK2TYK2JAK3CCNT1 | |
| SCHEMBL30669813 | 0.84 | JAK1 (0.46) | JAK1JAK2TYK2JAK3CCNT1 | |
| SCHEMBL24615244 | 0.82 | JAK1 (0.36) | JAK1JAK2TYK2CCNT1CDK9 | |
| SCHEMBL24615553 | 0.79 | PBK (0.38) | CCNT1CDK9DYRK1A | |
| Hydrochloric Acid SCHEMBL29772786 | 0.79 | PBK (0.38) | CCNT1CDK9DYRK1A | |
| SCHEMBL24615500 | 0.74 | JAK1 (0.51) | JAK1JAK2TYK2JAK3KDR | |
| SCHEMBL24615619 | 0.73 | JAK1 (0.56) | JAK1JAK2TYK2JAK3KDR | |
| SCHEMBL24615509 | 0.72 | TYK2 (0.51) | JAK1JAK2TYK2JAK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |