Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.56 |
| ▸ | JAK1 | P23458 | 11/20 | 0.56 |
| ▸ | TYK2 | P29597 | 11/20 | 0.56 |
| ▸ | JAK3 | P52333 | 4/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 6/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24615619 | 0.88 | JAK1 (0.56) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL24615337 | 0.87 | JAK2 (0.52) | JAK2JAK1TYK2JAK3KIT | |
| SCHEMBL29772793 | 0.87 | JAK2 (0.52) | JAK2JAK1TYK2JAK3KIT | |
| SCHEMBL24615501 | 0.85 | TYK2 (0.55) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL29772764 | 0.85 | TYK2 (0.55) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL24615492 | 0.85 | JAK1 (0.50) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL24615502 | 0.85 | JAK1 (0.48) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL24615536 | 0.83 | JAK1 (0.48) | JAK2JAK1TYK2KITAURKA | |
| SCHEMBL30669778 | 0.83 | JAK1 (0.48) | JAK2JAK1TYK2KITAURKA | |
| SCHEMBL27280129 | 0.83 | JAK1 (0.48) | JAK2JAK1TYK2KITAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |