Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29772743 | 1.00 | JAK1 (0.44) | JAK1GPR119RETHSD11B1JAK2 | |
| SCHEMBL30669815 | 1.00 | JAK1 (0.44) | JAK1GPR119RETHSD11B1JAK2 | |
| SCHEMBL29772810 | 0.87 | JAK1 (0.46) | JAK1GPR119RETHSD11B1JAK2 | |
| SCHEMBL24615515 | 0.86 | JAK1 (0.37) | JAK1GPR119RETJAK2TYK2 | |
| SCHEMBL24615405 | 0.83 | TYK2 (0.43) | JAK1JAK2TYK2JAK3WDR5 | |
| SCHEMBL24615246 | 0.82 | RET (0.46) | JAK1GPR119RETJAK2TYK2 | |
| SCHEMBL30669773 | 0.82 | RET (0.46) | JAK1GPR119RETJAK2TYK2 | |
| SCHEMBL30669796 | 0.77 | KIT (0.51) | JAK1GPR119RETTBK1 | |
| SCHEMBL29772837 | 0.77 | KIT (0.51) | JAK1GPR119RETTBK1 | |
| SCHEMBL24615482 | 0.76 | JAK1 (0.46) | JAK1GPR119HSD11B1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |