Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.48 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 12/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29772761 | 0.99 | AURKA (0.47) | AURKAAURKBINCENPTPX2TBK1 | |
| SCHEMBL24615321 | 0.85 | KIT (0.47) | KIT | |
| SCHEMBL24615318 | 0.82 | KIT (0.59) | KIT | |
| SCHEMBL27280802 | 0.82 | AURKA (0.43) | AURKAAURKBINCENPTPX2TBK1 | |
| Hydrochloric Acid SCHEMBL30726604 | 0.81 | KIT (0.58) | KIT | |
| SCHEMBL24615337 | 0.81 | JAK2 (0.52) | AURKAAURKBINCENPTPX2KIT | |
| SCHEMBL29772793 | 0.81 | JAK2 (0.52) | AURKAAURKBINCENPTPX2KIT | |
| SCHEMBL30559880 | 0.81 | PIM1 (0.51) | AURKAAURKBINCENPTPX2KIT | |
| SCHEMBL24615553 | 0.80 | PBK (0.38) | AURKAAURKBINCENPTPX2ROCK2 | |
| SCHEMBL24615543 | 0.80 | CSNK1D (0.38) | AURKAAURKBINCENPTPX2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006493-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2024-01-04 | — | — | WO | disclosed |
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |