SCHEMBL24615554

SCHEMBL24615554

O=C([C@@H]1C[C@H]1F)N1C2CCC1CN(c1ncnn3cc(-c4cnn(C(F)F)c4)cc13)C2

nearest known ligand 0.48

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24615315 1.00 KIT (0.48) KIT
SCHEMBL24615316 1.00 KIT (0.48) KIT
SCHEMBL24615399 0.90 KIT (0.52) KIT
SCHEMBL29772817 0.90 KIT (0.46) KIT
SCHEMBL24615576 0.90 KIT (0.46) KIT
SCHEMBL24615575 0.90 KIT (0.46) KIT
SCHEMBL24615365 0.89 KIT (0.48) KIT
SCHEMBL29772868 0.89 KIT (0.48) KIT
SCHEMBL29772822 0.89 KIT (0.49) KIT
SCHEMBL24615585 0.88 KIT (0.52) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117098763-A TYK2 inhibitors 渤健马萨诸塞州股份有限公司 2023-11-21 CN disclosed
EP-4274832-A1 TYK2 INHIBITORS Biogen MA Inc. (US) 2023-11-15 EP disclosed
WO-2022150446-A1 TYK2 INHIBITORS BIOGEN MA INC. (US) 2022-07-14 WO disclosed
WO-2022150446-A1 TYK2 INHIBITORS BIOGEN MA INC. (US) 2022-07-14 WO disclosed