Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24615958 | 0.84 | SMN1; SMN2 (0.40) | SMN1; SMN2USP2HPGD | |
| SCHEMBL30327046 | 0.77 | SMN1; SMN2 (0.39) | SMN1; SMN2USP2HPGDCYP1A2 | |
| SCHEMBL24615831 | 0.75 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP1A2 | |
| SCHEMBL23536294 | 0.74 | CYP2D6 (0.34) | USP2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL19014335 | 0.71 | SMN1; SMN2 (0.45) | SMN1; SMN2USP2HPGDCYP1A2CYP2C19 | |
| SCHEMBL17815708 | 0.71 | SCN9A (0.32) | — | |
| SCHEMBL23536071 | 0.70 | USP2 (0.45) | SMN1; SMN2USP2HPGD | |
| SCHEMBL24615832 | 0.69 | SMN1; SMN2 (0.36) | SMN1; SMN2 | |
| SCHEMBL30548544 | 0.68 | SMN1; SMN2 (0.50) | SMN1; SMN2USP2HPGDCYP1A2CYP2C19 | |
| SCHEMBL14970391 | 0.67 | SMN1; SMN2 (0.50) | SMN1; SMN2USP2HPGDCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148422-A1 | BRIDGED COMPOUNDS AS KRAS G12D INHIBITOR AND DEGRADER AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2022-07-14 | — | — | WO | disclosed |