Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.55 |
| ▸ | GRK2 | P25098 | 9/20 | 0.54 |
| ▸ | GRK1 | Q15835 | 2/20 | 0.48 |
| ▸ | GRK5 | P34947 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | GRK6 | P43250 | 1/20 | 0.47 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.47 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778991 | 1.00 | ROCK2 (0.55) | ROCK2ROCK1GRK2GRK1GRK5 | |
| SCHEMBL24617168 | 0.91 | ROCK2 (0.54) | ROCK2ROCK1GRK2GRK1GRK5 | |
| SCHEMBL29136094 | 0.89 | ROCK1 (0.56) | ROCK2ROCK1GRK2GRK1GRK5 | |
| SCHEMBL29778921 | 0.89 | ROCK1 (0.56) | ROCK2ROCK1GRK2GRK1GRK5 | |
| SCHEMBL24617050 | 0.89 | GRK2 (0.62) | ROCK2ROCK1GRK2GRK1GRK5 | |
| SCHEMBL24617068 | 0.89 | PDPK1 (0.53) | ROCK2ROCK1GRK2GRK1GRK5 | |
| SCHEMBL30656480 | 0.89 | GRK2 (0.62) | ROCK2ROCK1GRK2GRK1GRK5 | |
| SCHEMBL24616900 | 0.85 | ROCK2 (0.46) | ROCK2ROCK1GRK2PDPK1MAPK1 | |
| SCHEMBL24616951 | 0.85 | ROCK2 (0.47) | ROCK2ROCK1GRK2AURKAMAPK1 | |
| SCHEMBL29135966 | 0.85 | GRK2 (0.69) | ROCK2ROCK1GRK2GRK1GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |