Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.72 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.72 |
| ▸ | GRK2 | P25098 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | PRKCB | P05771 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.59 |
| ▸ | GRK5 | P34947 | 1/20 | 0.59 |
| ▸ | GRK6 | P43250 | 1/20 | 0.59 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.59 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.59 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.59 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.51 |
| ▸ | QPCT | Q16769 | 1/20 | 0.51 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30656425 | 1.00 | ROCK2 (0.72) | ROCK2ROCK1GRK2AURKAPRKCB | |
| SCHEMBL24617688 | 0.89 | ROCK2 (0.69) | ROCK2ROCK1GRK2AURKAPRKCB | |
| SCHEMBL30656550 | 0.84 | ROCK2 (0.66) | ROCK2ROCK1GRK2AURKAPRKCB | |
| SCHEMBL24617265 | 0.84 | ROCK2 (0.66) | ROCK2ROCK1GRK2AURKAPRKCB | |
| SCHEMBL24617407 | 0.82 | GRK2 (0.85) | ROCK2ROCK1GRK2AURKAPRKCB | |
| SCHEMBL30656470 | 0.82 | ROCK2 (0.62) | ROCK2ROCK1GRK2AURKAPRKCB | |
| SCHEMBL30656542 | 0.81 | ROCK2 (0.49) | ROCK2ROCK1GRK2GRK1 | |
| SCHEMBL24617530 | 0.81 | ROCK2 (0.49) | ROCK2ROCK1GRK2GRK1 | |
| SCHEMBL24617406 | 0.80 | ROCK2 (0.62) | ROCK2ROCK1GRK2AURKAPRKCB | |
| SCHEMBL29778896 | 0.80 | ROCK2 (0.62) | ROCK2ROCK1GRK2AURKAPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150381-A1 | SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2022-07-14 | — | — | WO | disclosed |