Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24618455 | 0.84 | ALDH1A1 (0.51) | MAPTKMT2AMEN1POLBNPC1 | |
| SCHEMBL24618645 | 0.84 | KMT2A (0.40) | MAPTKMT2AMEN1POLBNPC1 | |
| SCHEMBL24618635 | 0.83 | KMT2A (0.49) | MAPTKMT2AMEN1POLBNPC1 | |
| SCHEMBL24618202 | 0.82 | KMT2A (0.38) | MAPTKMT2AMEN1POLBNPC1 | |
| SCHEMBL24618628 | 0.81 | MAPT (0.38) | MAPTKMT2AMEN1POLBNPC1 | |
| SCHEMBL24618407 | 0.80 | MAPT (0.47) | MAPTKMT2AMEN1POLBNPC1 | |
| SCHEMBL14341760 | 0.75 | KDM4E (0.42) | MAPTKMT2AMEN1POLBNPC1 | |
| SCHEMBL30437857 | 0.74 | ALDH1A1 (0.38) | MAPTKMT2AMEN1POLBGAA | |
| SCHEMBL3418500 | 0.72 | AURKA (0.55) | MAPTKMT2AMEN1POLBNPC1 | |
| SCHEMBL29791714 | 0.72 | MAP4K4 (0.38) | MAPTKMT2AMEN1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022149167-A1 | DIAMINOPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBONITRILE COMPOUNDS AS ADENOSINE 2A RECEPTOR AND ADENOSINE 2B RECEPTOR ANTAGONIST | BUGWORKS RESEARCH INDIA PVT LTD (IN) | 2022-07-14 | — | — | WO | disclosed |