Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 18/20 | 0.75 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086296 | 0.86 | BACE1 (0.70) | BACE1KCNH2BACE2 | |
| SCHEMBL2463159 | 0.85 | BACE1 (0.63) | BACE1KCNH2BACE2 | |
| SCHEMBL2462010 | 0.85 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL3544023 | 0.85 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL2085760 | 0.85 | BACE1 (0.78) | BACE1KCNH2BACE2 | |
| SCHEMBL3549935 | 0.85 | BACE1 (0.74) | BACE1KCNH2BACE2 | |
| SCHEMBL2084642 | 0.84 | BACE1 (0.74) | BACE1KCNH2BACE2 | |
| SCHEMBL2086963 | 0.84 | BACE1 (0.74) | BACE1KCNH2BACE2 | |
| SCHEMBL2087779 | 0.83 | BACE1 (0.58) | BACE1KCNH2BACE2 | |
| SCHEMBL2086614 | 0.82 | BACE1 (0.51) | BACE1KCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367814-A1 | NEW COMPOUNDS 578 | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | claimed |
| WO-2010056196-A1 | NEW COMPOUNDS 578 | ASTRAZENECA AB (SE) | 2010-05-20 | — | — | WO | claimed |