Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24620199 | 0.71 | IGF1R (0.34) | JAK1JAK3MAPK1MAPK3MAP2K1 | |
| SCHEMBL24620354 | 0.70 | BRD4 (0.47) | BRD4JAK1JAK2JAK3PDGFRB | |
| SCHEMBL24620202 | 0.67 | MAP4K1 (0.41) | BTK | |
| SCHEMBL24620594 | 0.66 | PDGFRB (0.38) | BRD4JAK1JAK2JAK3PDGFRB | |
| SCHEMBL24620485 | 0.64 | BTK (0.47) | BTK | |
| SCHEMBL24620488 | 0.64 | MAP4K1 (0.42) | JAK2FLT3BTK | |
| SCHEMBL24620276 | 0.64 | BTK (0.45) | BRD4BTK | |
| SCHEMBL24620300 | 0.63 | ALK (0.55) | BRD4PDGFRBPDGFRAMAPK3 | |
| SCHEMBL30833013 | 0.63 | ALK (0.55) | BRD4PDGFRBPDGFRAMAPK3 | |
| SCHEMBL24620264 | 0.61 | MAP4K1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |