Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24620488 | 0.83 | MAP4K1 (0.42) | BTKMAP4K1CDK4ALK | |
| SCHEMBL24620485 | 0.83 | BTK (0.47) | BTKMAP4K1ALK | |
| SCHEMBL24620264 | 0.80 | MAP4K1 (0.56) | MAP4K1 | |
| SCHEMBL24620188 | 0.80 | MAP4K1 (0.56) | MAP4K1 | |
| SCHEMBL24620202 | 0.76 | MAP4K1 (0.41) | BTKMAP4K1ALK | |
| SCHEMBL24620377 | 0.74 | ALK (0.57) | MAP4K1ALK | |
| SCHEMBL30833012 | 0.74 | ALK (0.57) | MAP4K1ALK | |
| SCHEMBL24620199 | 0.74 | IGF1R (0.34) | CDK6 | |
| SCHEMBL24620455 | 0.74 | MAP4K1 (0.51) | BTKMAP4K1ALK | |
| SCHEMBL24620354 | 0.73 | BRD4 (0.47) | CDK6ALKBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |