Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.51 |
| ▸ | INSR | P06213 | 12/20 | 0.49 |
| ▸ | IGF1R | P08069 | 12/20 | 0.49 |
| ▸ | PLK1 | P53350 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | STK10 | O94804 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.46 |
| ▸ | FES | P07332 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | YES1 | P07947 | 2/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24620501 | 0.95 | ALK (0.49) | ALKINSRIGF1RPLK1EGFR | |
| SCHEMBL24620360 | 0.92 | ALK (0.58) | ALKINSRIGF1RPLK1EGFR | |
| SCHEMBL24620371 | 0.80 | EGFR (0.45) | ALKINSRIGF1RPLK1EGFR | |
| SCHEMBL24620309 | 0.79 | PLK1 (0.44) | ALKINSRIGF1RPLK1EGFR | |
| SCHEMBL24620277 | 0.78 | PTK2 (0.44) | ALKINSRIGF1RPLK1EGFR | |
| SCHEMBL24620386 | 0.78 | PLK1 (0.43) | ALKINSRIGF1RPLK1EGFR | |
| SCHEMBL24620620 | 0.76 | ALK (0.57) | ALKINSRIGF1RPLK1EGFR | |
| SCHEMBL24620344 | 0.75 | ALK (0.58) | ALKINSRIGF1RPLK1EGFR | |
| SCHEMBL24326984 | 0.74 | ALK (0.60) | ALKINSRIGF1RPLK1EGFR | |
| SCHEMBL30833015 | 0.72 | ALK (0.56) | ALKINSRIGF1RPLK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |